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I behandelten Psoriasis Wasserstoffperoxid Patent DET2 - Pharmazeutische zusammensetzungen enthaltend resveratrol und verwendungen - Google Patents I behandelten Psoriasis Wasserstoffperoxid


Patenten Try the new Google Use of cyclohexanol ethers having antimicrobial properties WO A1. Samenvatting. Teebaumöl, Wasserstoffperoxid.

Therefore, the dyes are also distinguished by a differently strong adhesion to an ability to connect to the respective matrix of. Often in http://feuervogel-online.de/geschichte-der-krankheit-psoriasis-diagnose.php used dyes this connection capability is just weak, so that the dye can be quickly washed out by, for example, sweat or water.

Due to the low connection ability of the dye to the respective matrix the fertility of the dye in the dyeing process also is low and, consequently, the intensity of the color of matrices to be very pronounced.

When using, I behandelten Psoriasis Wasserstoffperoxid particular, synthetic dyes can, especially in the human scope, also low compatibility are present. In the preparation and storage of these compounds is carried out under inert conditions, for example, the absence of oxygen, as the substances are sensitive to oxidation by ascorbic acid-base. According to the invention this problem is solved by the subject matters of the independent claims.

Advantageous embodiments are subject of the dependent claims. It has now been found, surprisingly, that the compounds of formula I, as described below, are suitable as protein-adhesive dyes in an outstanding manner.

The term protein-adhesive dye is understood to mean a dye which binds I behandelten Psoriasis Wasserstoffperoxid a protein-containing matrix from at least one adhesion. Bevorzugte keratinhaltige Fasern sind Haare.

Preferred keratin fibers are hair. Besonders bevorzugte keratinhaltige Fasern sind menschliche Haare. Particularly preferred keratin fibers are human hair. Bindung an eine Amino- oder ThioIgruppe der Matrix ausbilden.

The protein- adhesive dyes can therefore interact physically with the matrix or form a covalent bond. Due to the amphiphilicity of the compounds of formula I, as described below, and surface active properties. Besonders bevorzugt sind die Verbindungen der Formel I, wie nachfolgend Particularly preferred are the compounds of formula I, as described below.

Die Verbindungen der Formel I, wie nachfolgend beschrieben, sind ebenfalls filmbildende Farbstoffe. The compounds of formula I, as described below, are also film-forming dyes. When keratin fibers the uniform dyeing result can be obtained from the root to the end of the fiber. Thiol groups is ensured. Ein erster Gegenstand der Erfindung sind demzufolge die Verbindungen der Formel I, A first object of the present invention accordingly provides the compounds of formula I. E NR 4 oder O bedeutet, E NR 4 or O.

Sp I behandelten Psoriasis Wasserstoffperoxid Bindung, alk, -C O - http://feuervogel-online.de/thiosulfat-psoriasis-bewertungen.php - CO -alk bedeutet, Sp is a bond, alk, -C O - or - CO -Alk means. D ein Farbchromophor bedeutet, D a Farbchromophor means. X das Gegenion zu der [COO " ]-Gruppe ist, X, the counter ion to the [COO "] group is. R I behandelten Psoriasis Wasserstoffperoxid A bedeutet, R 4, A means.

Ein weiterer Gegenstand der Erfindung ist I behandelten Psoriasis Wasserstoffperoxid die Verwendung von Verbindungen der Formel I, Another object of the invention is therefore the use of compounds of the formula I. Im Rahmen der Erfindung sind die Verbindungen der Formel I, so definiert, dass man darunter auch pharmazeutisch oder kosmetisch verwendbare Derivate, Salze, Hydrate, Solvate, Vorstufen der Verbindungen, Tautomere und optisch aktive Formen wie zB Stereoisomere, Diastereomere, Enantiomere, Racemate versteht.

In the context of the invention are the compounds of formula I, defined as including pharmaceutically or cosmetically usable derivatives, salts, hydrates, solvates, precursors of the compounds, tautomers and optically-active forms for example, stereoisomers, diastereomers, enantiomers, racemates one understood. Solvates of the compounds are taken to mean of inert solvent molecules onto I behandelten Psoriasis Wasserstoffperoxid compounds which form owing to their mutual attractive force.

Solvate sind zB Mono- oder Dihydrate oder Alkoholate. Solvates are mono- or dihydrates or alcoholates. By pharmaceutically or cosmetically usable derivatives are understood as the salts of the compounds of the invention.

The compounds of formula I can cis-trans isomers or I behandelten Psoriasis Wasserstoffperoxid form. The formula I includes all these forms. Solvents such as ethanol and subsequent evaporation. Particularly suitable acids are those which yield physiologically acceptable salts for this reaction.

It is preferred from the linear or branched alkyl group having 1 to 20 carbon atoms, the straight-chain I behandelten Psoriasis Wasserstoffperoxid branched alkyl group having 1 to 8 carbon atomsie. Methyl, Ethyl, Isopropyl, Propyl, Butyl, sec-Butyl oder tert-Butyl, weiterhin Pentyl, 1- 2- oder 3-Methylbutyl, 1 ,1- 1,2- oder 2,2-Dimethylpropyl, Methyl, ethyl, I behandelten Psoriasis Wasserstoffperoxid, propyl, butyl, sec-butyl or tert-butyl, furthermore pentyl, 1- 2- or 3-methylbutyl, I behandelten Psoriasis Wasserstoffperoxid, 1- 1,2- or 2,2-dimethylpropyl.

Particularly preferred are the straight-chain or branched alkyl group is derived from the I behandelten Psoriasis Wasserstoffperoxid or branched alkyl group having 1 to 20 carbon atoms selected from 1 to I behandelten Psoriasis Wasserstoffperoxid carbon atoms, ie, methyl, ethyl, isopropyl, propyl, butyl, sec-butyl or I behandelten Psoriasis Wasserstoffperoxid. The abbreviation "alk" represents a linear or branched or cyclic alkylene group having 1 to 18 carbon atoms derived from the above-described alkyl groups having 1 I behandelten Psoriasis Wasserstoffperoxid 18 carbon atoms.

Preferably, Alk is methylene, ethylene, propylene or butylene. Accordingly, the abbreviation for NHA and alkylamino-NA 2 represents dialkylamino. In one embodiment, compounds of formula I are preferred in which the substituent R1 A and A one of the meanings given above, or has the meanings given as being preferred. Besonders bevorzugt ist R 1 Methyl oder Ethyl.

Particularly preferably, R 1 is methyl or ethyl. Ganz besonders bevorzugt ist R1 Methyl. Very particularly preferably R1 is methyl. In one embodiment, compounds of formula I are preferred in which the substituent R 2 H - CH 2 P -OH, -C 0 OA, COOH or COOX, where A, I behandelten Psoriasis Wasserstoffperoxid and p is an above-mentioned or preferred mentioned have meaning.

Besonders bevorzugt ist der Substituent R 2 H, Hydroxymethyl oder -C 0 OEthyl oder -C O OMethyl. Particularly preferred is the substituent R 2 is H, hydroxymethyl or I behandelten Psoriasis Wasserstoffperoxid 0 OEthyl or -C O Omethyl.

Ganz besonders bevorzugt ist der Substituent R 2 H. Most preferably, the substituent R 2 is H. In one embodiment, compounds of formula I are preferred in which the substituent R 3 is H. In a preferred embodiment compounds of formula I are preferred in which R 2 and R 3 is H, the substituents.

In one embodiment, compounds of formula I are preferred in which the substituent R 4 I behandelten Psoriasis Wasserstoffperoxid A, and A has one of the meanings given as being preferred. Besonders bevorzugt ist R 4 Methyl oder Ethyl. More preferably, R 4 is methyl or ethyl.

Ganz besonders bevorzugt I behandelten Psoriasis Wasserstoffperoxid R4 Methyl. R4 is very particularly preferably methyl.

In a preferred embodiment, compounds of formula I are preferred I behandelten Psoriasis Wasserstoffperoxid which the variable or EO.

Demzufolge sind die Verbindungen der Formeln la, lb, lc und ld besonders bevorzugt: Accordingly, the compounds of the formulas la, lb, lc and ld are particularly preferred: Bedeutungen haben oder eine der nachfolgend angegebenen bevorzugten Bedeutungen haben. In one embodiment, compounds of formula I are preferred in which the EO variable means. In one embodiment, compounds of formula I are preferred in which the variable E is NR 4 and R 4 A is, where A has one of the meanings given above or, preferably, specified.

Bevorzugt bedeutet die Variable E N-Methyl. Preferably means the variable E N-methyl. In I behandelten Psoriasis Wasserstoffperoxid embodiment, the compounds of the formula la or lb are particularly preferred. In this embodiment, the compounds of formula la are especially preferred. In a preferred embodiment compounds of formula I are preferred in which the variable E is NR 4, and the I behandelten Psoriasis Wasserstoffperoxid R 4, 3, R2, i. Sp und Patch-Psoriasis eine der zuvor angegebenen oder nachfolgend angegebenen bevorzugten Bedeutungen oder besonders bevorzugt angegebenen Bedeutungen haben.

In this embodiment, the compounds of formula lc or ld are particularly preferred. In this embodiment, the compounds of formula lc are very particularly preferred. In a preferred embodiment compounds of formula I, la, lb, lc or ld are preferred in which the variable Sp -C O.

The nature of the Farbchromophors D is not limited in the context of the present invention. Go here vorteilhaften Eigenschaften der Verbindungen der Read more I, la, lb, lc oder ld, wie zuvor beschrieben, werden durch die Struktureinheit der Formel erzielt, The advantageous properties of the compounds of formula I, la, lb, lc I behandelten Psoriasis Wasserstoffperoxid ld, as previously described, are achieved by the structural unit of Formula.

Bevorzugt leitet sich das Farbchromophor D von einem Preferably the Farbchromophor D derives from a. Farbstoff ab, der Strahlung im sichtbaren Bereich zwischen und nm absorbiert.

From dye which absorbs radiation in the visible range between and nm. Das Farbchromophor D kann auch von link fluoreszierenden Farbstoff abgeleitet sein, so dass eine Verbindung der Formel I, la, lb, lc oder ld enthaltend dieses fluoreszierende Farbchromophor auch auf einer bereits dunkel erscheinenden Matrix sichtbar wird.

The Farbchromophor D can also be derived from a fluorescent dye, so that a compound of formula I, la, I behandelten Psoriasis Wasserstoffperoxid, Ic or ld this fluorescent Farbchromophor on an already dark appearing matrix containing visible.

Ein fluoreszierendes Farbchromophor D leitet sich von einem A fluorescent Farbchromophor D derives from a. Bevorzugt leitet sich das fluoreszierende Farbchromophor D von einem fluoreszierenden Farbstoff ab, der Strahlung im sichtbaren I behandelten Psoriasis Wasserstoffperoxid zwischen und nm absorbiert und Strahlung zwischen und nm emittiert. Preferably, the fluorescent Farbchromophor D of the radiation in the visible range between and nm derived from a fluorescent dye absorbs and link radiation from to nm.

Besonders bevorzugt leitet sich das fluoreszierende Particularly preferably directs the fluorescent. Farbchromophor D von einem fluoreszierenden Farbstoff ab, der Strahlung im sichtbaren Bereich zwischen und nm absorbiert und Strahlung zwischen und nm emittiert. Farbchromophor D of a fluorescent dye from the radiation in the visible region from to nm absorbs and emits radiation from to nm. Das Farbchromophor D kann demzufolge vonn den folgenden Farbstoffen abgeleitet werden: Acridinfarbstoffe, Acridonfarbstoffe, Anthrapyrimidinfarbstoffe, The Farbchromophor D can therefore be derived vonn the following dyes: Anthrachinonfarbstoffe, Azinfarbstoffe, Poly -Azofarbstoffe, Anthraquinone dyes, azine dyes, poly -Azofarbstoffe.

Hydrazonofarbstoffe, Hydrazonfarbstoffe, bevorzugt Arylhydrazonfarbstoffe, Azomethinfarbstoffe, Benzanthronfarbstoffe, Benzimidazolfarbstoffe, Benzimidazolonfarbstoffe, Benzindolfarbstoffe, Benzoxazolfarbstoffe, Benzopyranfarbstoffe, Benzothiazolfarbstoffe, Benzochinonfarbstoffe, Bisazinfarbstoffe, Bis-Isoindolinfarbstoffe, Carboxanilidfarbstoffe, Hydrazonofarbstoffe, hydrazone, preferably Arylhydrazonfarbstoffe, azomethine, Benzanthronfarbstoffe, Benzimidazolfarbstoffe, Benzimidazolonfarbstoffe, Benzindolfarbstoffe, Benzoxazolfarbstoffe, benzopyran, Benzothiazolfarbstoffe, benzoquinone, Bisazinfarbstoffe, bis-isoindoline, Carboxanilidfarbstoffe.

Coumarinfarbstoffe, Cyaninfarbstoffe, beispielsweise Merocyaninfarbstoffe, Azacarbocyaninfarbstoffe, Diazacarbocyaninfarbstoffe, Coumarin dyes, cyanine dyes, such as merocyanine, azacarbocyanine dyes, Diazacarbocyaninfarbstoffe.

Diazahemicyaninfarbstoffe, Hemicyaninfarbstoffe oder Diazahemicyaninfarbstoffe, hemicyanine or. Tetraazacarbocyaninfarbstoffe, Diazinfarbstoffe, Tetraazacarbocyaninfarbstoffe, Diazinfarbstoffe. Diketopyrrolopyrrolfarbstoffe, Dioxazinfarbstoffe, Diphenylaminfarbstoffe, Diphenylmethanfarbstoffe, Dithiazinfarbstoffe, Flavonoide beispielsweise Flavanthrone und Flavone, Fluorindinfarbstoffe, Formazanfarbstoffe, Indaminfarbstoffe, Indanthronfarbstoffe, Indigoide und Pseudo-Indigoide, Indophenolfarbstoffe, Indoanilinfarbstoffe, Isoindolinfarbstoffe, Diketopyrrolopyrrolfarbstoffe, dioxazine, Diphenylaminfarbstoffe, diphenylmethane, Dithiazinfarbstoffe, flavonoids example flavanthrones and flavones, Fluorindinfarbstoffe, formazan dyes, Indaminfarbstoffe, Indanthronfarbstoffe, indigoid and pseudo indigoid, indophenol, indoaniline, isoindoline.

Isoindolinonfarbstoffe, Isoviolanthronfarbstoffe, Lactonfarbstoffe, I behandelten Psoriasis Wasserstoffperoxid, Isoviolanthronfarbstoffe, Lactonfarbstoffe. Poly methinfarbstoffe, beispielsweise Dimethinfarbstoffe I behandelten Psoriasis Wasserstoffperoxid Stilben- oder Styrol-Typ, Naphthalimidfarbstoffe, Naphthanilidfarbstoffe, Poly methine example dimethine from stilbene or styrene type, naphthalimide, Naphthanilidfarbstoffe.

Naphtholactamfarbstoffe, Naphthochinonfarbstoffe, Farbstoffe enthaltend mindestens eine N0 2 -Gruppe, Oxadiazolfarbstoffe, Oxazinfarbstoffe, Perilonfarbstoffe, Perinonfarbstoffe, Perylenfarbstoffe, Phenazinfarbstoffe, Phenoxazinfarbstoffe, Phenothiazinfarbstoffe, Phthalocyaninfarbstoffe, Polyene oder Carotinoide, Porphyrinfarbstoffe, Pyranthronfarbstoffe, Pyrazolanthronfarbstoffe, Pyrazolonfarbstoffe, Pyrimidinoanthronfarbstoffe, Pyroninfarbstoffe, Chinacridonfarbstoffe, Chinolinfarbstoffe, Naphtholactam, naphthoquinone dyes Was ist guttata at least one N0 2 group, Oxadiazolfarbstoffe, oxazine, Perilonfarbstoffe, perinone, perylene, phenazine, phenoxazine, phenothiazine, phthalocyanine dyes, polyenes or carotenoids, porphyrin, Pyranthronfarbstoffe, Pyrazolanthronfarbstoffe, pyrazolone, Pyrimidinoanthronfarbstoffe, Pyroninfarbstoffe, quinacridone, quinoline.

Chinophathalonfarbstoffe, Swuaranfarbstoffe, Tetrazolfarbstoffe, Chinophathalonfarbstoffe, Swuaranfarbstoffe, Tetrazolfarbstoffe. Thiazinfarbstoffe, Thioindigofarbstoffe, Thiopyroninfarbstoffe, Thiazine, thioindigo, Thiopyroninfarbstoffe. R b H oder A bedeutet, R b denotes H or A.

R e eine Alkylgruppe mit 1 bis 6 C-Atomen bedeutet, die durch mindestens eine Gruppe NA 2 oder NA 3 Y substituiert ist, R e represents an alkyl group having 1 to 6 carbon atoms, which is substituted by at least one group NA NA 2 or 3 Y.

A eine lineare oder verzweigte Alkylgruppe mit 1 bis 20 C-Atomen bedeutet, A means a linear or branched alkyl group having 1 to 20 carbon atoms. Hai F, Cl, Br oder I bedeutet und Hal denotes F, Cl, Br or I, and. The abbreviation "A" described above and the comments on "A", "OA", "NHA", NA 2 "apply mutatis mutandis to the formulas II to XII.

Hai bedeutet Halogen oder mit anderen Worten F, Cl, Br oder I. Hai ist bevorzugt Br oder l. Hal is halogen, or in other words, F, Cl, Br or I. Hai is I behandelten Psoriasis Wasserstoffperoxid Br or l. The anion Y represents an organic or inorganic acid that is compatible pharmacologically or cosmetically or a cation.

Die Variable m bedeutet 0, 12, 3, 4 oder 5. Bevorzugte Bedeutungen werden bei den Formeln II bis XII spezifisch angegeben. The variable m represents 0, 1, 2, 3, 4 or 5. Preferred meanings are given specifically in the formulas II to XII. Farbchromophor D gelistet, der durch die Formeln II, III, IV, V, VI, VII, VIII, IX, X, XI und XII beschrieben wird.

Farbchromophor listed D, which is described by the formulas II, III, IV, V, VI, VII, VIII, IX, X, XI and XII. Each preferred or particularly preferred embodiment of the above formulas II to XII can be combined with one or more of said preferred or particularly preferred embodiments of the rest of the formulas II to XII, the selection of the Farbchromophors D in the compounds of formula I, la, lbpreferred to describe lc or ld.

In a further embodiment, the substituents of formula II Rj is H and R a and R b are each independently A, wherein A is one of the previously mentioned meanings given as being preferred or. In Formel II ist m bevorzugt 1.

In Formel II ist Y bevorzugt Chlorid, Bromid, ein Alkylsulfat oder In a further embodiment, the substituents of formula II, R, H, and R a and R b are each independently A, where A has one of the meanings given as preferred meanings indicated, or and R g is H.

In Formula II, m is I behandelten Psoriasis Wasserstoffperoxid 1. In formula II, Y is preferably chloride, bromide, or an alkyl sulfate. Alkylethersulfat, wie zB Laurylsulfat oder Laurylethersulfat.

Alkyl ether, such as lauryl visit web page or lauryl ether sulfate. A case has one of the previously mentioned meanings or meanings indicated as preferred, said alkyl groups having 1 to 20 carbon atoms, may additionally be substituted with at least one OH group.

In formula III R c and R d are more preferably selected from methyl or 2-hydroxy-ethyl. In Formel III ist R b bevorzugt H. In Formel III ist m bevorzugt 2 oder 3, besonders bevorzugt 2. In Formel III ist Y bevorzugt Chlorid, Bromid, ein Alkylsulfat oder In formula III R b is preferably H. In formula III, m is preferably 2 or 3, particularly preferably 2. In formula III, Y is preferably chloride, bromide, or an alkyl sulfate.

In Formel IV ist m bevorzugt 1. In Formel IV ist Y bevorzugt Chlorid, Bromid, ein Alkylsulfat oder In Formula IV, m is preferably 1. In formula IV, I behandelten Psoriasis Wasserstoffperoxid is preferably chloride, bromide, or an alkyl sulfate.

In one embodiment, for the substituents of formula V R a is methyl. In a further embodiment, the substituents of formula V R a is methyl and R c and R d are each the same, wherein A is preferably selected from a linear or branched alkyl group having 1 to 8 carbon atoms or a linear or branched alkyl group having 1 to 8 carbon atoms which is substituted with an OH group.

In Formel V werden R I behandelten Psoriasis Wasserstoffperoxid und R d In formula V R c and R d. In Formel V ist m bevorzugt 3. In Formel V ist Y bevorzugt Chlorid, Bromid, ein Alkylsulfat oder Alkylethersulfat, wie zB Laurylsulfat oder In Formula V, m I behandelten Psoriasis Wasserstoffperoxid preferably 3. In the formula V, Y is preferably chloride, bromide, an alkyl sulfate or pharmacokinetics Chinesische Salbe für Psoriasis Kreifseiide ether sulfate, such as lauryl sulfate or.

In one embodiment, for the substituents of I behandelten Psoriasis Wasserstoffperoxid VI, R b is methyl. In a further embodiment, the substituents of formula VI, R b is methyl and R A is identical in each case, where A has one of the meanings given as being preferred or given meanings.

In Formel In formula. I behandelten Psoriasis Wasserstoffperoxid ist m bevorzugt 1. In Formel VI ist Y bevorzugt Chlorid, Bromid, ein Alkylsulfat oder Alkylethersulfat, wie zB Laurylsulfat oder Laurylethersulfat. VI, m is preferably 1. In formula VI, Y I behandelten Psoriasis Wasserstoffperoxid preferably chloride, bromide, an alkyl sulfate or alkyl ether sulfate, such as lauryl ether sulphate or lauryl sulphate.

In a further embodiment of the substituent of formula. In Formel VII ist R g bevorzugt H. In formula VII Source g is preferably H.

Formel VII ist m bevorzugt 3 oder 4, besonders bevorzugt 3. In Formel VII ist Y bevorzugt Chlorid, Bromid, ein Alkylsulfat oder Alkylethersulfat, wie zB Laurylsulfat oder Laurylethersulfat.

Formula VII, m is preferably 3 or 4, particularly preferably 3. In formula VII, Y is preferably chloride, bromide, an alkyl sulfate I behandelten Psoriasis Wasserstoffperoxid alkyl ether sulfate, such as lauryl ether sulphate or lauryl sulphate. In one embodiment, for the substituents of formula VIII R b is H or methyl. In Formel VIII sind R c und R d bevorzugt beide H oder beide Methyl. In formula VIII R c and R d are preferably both H or both methyl. In Formel VIII ist m bevorzugt 3 oder 4, besonders bevorzugt 3.

In Formula VIII, m is preferably 3 or 4, particularly preferably 3. In the formula VIII Y is preferably sodium, potassium, ammonium, or a quaternary ammonium compound. In one embodiment, for the substituents of formula IX, R b is methyl.

In Formel IX ist m bevorzugt 1. In a further embodiment, the substituents of formula IX R b I behandelten Psoriasis Wasserstoffperoxid methyl, and R g is H. In formula IX, m is preferably 1.

In formula IX, Y is sodium, potassium, ammonium, or a quaternary ammonium compound. In Formel X ist R s bevorzugt H oder NA2, wobei A eine zuvor angegebene Bedeutung oder eine als bevorzugt angegebene Bedeutung hat. In one embodiment, for the substituent of the formula X m is 0. In another embodiment, the substituents X of the formula m is 0 and Rg is H. In formula X, R s is preferably H or NA2, and A is a I behandelten Psoriasis Wasserstoffperoxid above, or has a meaning preferably specified as.

In one embodiment, for the substituents of formula XI R is H. In a further embodiment, the substituents of formula Salbe Psoriasis Dayvoneks, R b is H and R e is I behandelten Psoriasis Wasserstoffperoxid alkyl group having 3 carbon atoms, by at least one group NA NA 2 or 3 Y substituted, wherein a has a I behandelten Psoriasis Wasserstoffperoxid indicated above or a meaning preferably specified as.

In Formel XI ist m bevorzugt 5. In Formel XI ist Y bevorzugt Chlorid, Bromid, ein In formula XI m is preferably 5. In Formula XI, Y is I behandelten Psoriasis Wasserstoffperoxid chloride, bromide, a. Alkylsulfat oder Alkylethersulfat, wie zB Laurylsulfat oder Laurylethersulfat. Alkyl sulfate or alkyl ether, such as lauryl sulfate or lauryl ether sulfate.

In Psoriasis der Kopfhaut zu embodiment, for the substituents of formula XII, R b is methyl.

In Formel XII ist m bevorzugt 1. In Formel XII ist m bevorzugt 5. In Formel XI ist Y bevorzugt Chlorid, Bromid, ein Alkylsulfat oder In formula XII is preferably 1. Particularly preferred embodiments of the radical D can be seen in I behandelten Psoriasis Wasserstoffperoxid fol part structures: Vllc Y- VIIc Y. Ganz besonders bevorzugt entspricht D der Formel X, wobei R g und R s eine zuvor angegebene Bedeutung oder bevorzugte Bedeutung I behandelten Psoriasis Wasserstoffperoxid, insbesondere den Teilformeln Xa bis Xe entsprechen.

Very particularly preferably corresponds to the formula D X, wherein R g and R s have a meaning indicated above or preferred meaning, in particular comply with the sub-formulas Xa to Xe. Die Herstellung I behandelten Psoriasis Wasserstoffperoxid Verbindungen der Formel I, la, lb, lc, ld, wie zuvor beschrieben, kann dabei nach dem Fachmann an sich aus der Literatur bekannten Methoden erfolgen. The preparation of the compounds of formula I, la, lb, lc, ld, as described above, can be carried out by the skilled person per se known from the literature.

The reaction conditions for esterification or etherification are standard prior art, and the selection of suitable reaction conditions is standard expertise of synthesis specialist.

Gegenstand der Erfindung ist ebenfalls ein Verfahren zur Herstellung von Verbindungen der Formel I, la, lb, lc, ld, wie zuvor beschrieben oder als bevorzugt beschrieben, dadurch gekennzeichnet, dass eine Verbindung der Formel XIII The invention I behandelten Psoriasis Wasserstoffperoxid also a process for the preparation of compounds of formula I, la, lb, lc, ld, as previously described or described as preferable, characterized in that a compound of formula XIII.

D-Sp-M XIV D-Sp-M XIV. M alkali metal or alkaline earth metal cation, halogen, OH or H or a compound of formula XIII wherein R 2, R 3, R 4 and E have the meaning given above, is reacted with an active ester of the compound of formula XIV, derived from the free acid of formula XIV in which M OH and Sp-C O - and D has a previously stated meaning. The compounds of Formula XIII are commercially available in some cases, for example, 3-hydroxymethylpyranone, or can be prepared by known literature methods, for example, based on R.

Suzuki et al, Heterocyles,6oder A. Fassihi et al, European Journal of Medicinal Chemistry,44 5 Suzuki et al, Heterocyles,6or A.

Standardwerken wie Houben-Weyl, Methoden der organischen Chemie, Georg-Thieme- Verlag, Stuttgart beschrieben sind, und zwar unter Standard works such as Houben-Weyl, Methods of Organic Chemistry, Georg-Thieme-Verlag, Stuttgart, to be precise under.

Reaction conditions which are known and suitable for the reactions mentioned. Use can also make use of known per se, are not detailed here variants. Die Reaktionszeit liegt je nach den angewendeten Bedingungen zwischen einigen Minuten und mehreren Tagen.

The reaction time, depending on the conditions used, between a few minutes and several days. Of formula I, as previously described, an acid halide or an active ester of the free acid of formula XIV used for the synthesis of the compounds, a classical nucleophilic substitution takes place. The reaction conditions of a nucleophilic substitution are the synthesis skilled well known. Preferred acid halides of the formula XIV are acid chlorides. Wird eine Verbindung der Formel XIII, wie zuvor beschrieben, Is a compound of formula XIII, as described above.

Farbchromophor bedeutet, wie zuvor beschrieben, so findet die Farbchromophor means, as described above, it is found that. Kupplungsreaktion vorzugsweise in Gegenwart I behandelten Psoriasis Wasserstoffperoxid Coupling reaction preferably in the presence of a.

Dehydratisierungsmittels, zB eines Carbodiimids wie Dehydrating agent, for example a carbodiimide such as. Carboxylic acid or a carboxylic acid halide, a symmetrical or mixed anhydride or an active ester, can be used. Derartige Reste zur I behandelten Psoriasis Wasserstoffperoxid der Carboxygruppe in typischen Acylierungsreaktionen sind in der Literatur zB in den Standardwerken wie Houben-Weyl, Methoden der organischen Chemie, Georg-Thieme- Verlag, Stuttgart beschrieben.

Such radicals for activating the carboxyl group in typical acylation reactions are described in the literature eg in the standard I behandelten Psoriasis Wasserstoffperoxid such as Houben-Weyl, Methods of Organic Chemistry, Georg-Thieme-Verlag, Stuttgart. Activated esters are advantageously formed in situ, eg by addition of HOBt 1-hydroxybenzotriazole or N-hydroxysuccinimide. Dimethylanilin, Pyridin, Dimethylaminopyridin oder Chinolin.

Dimethylaniline, pyridine, dimethylaminopyridine or quinoline. Compounds of the formula I, as described above, are also suitable as Antiglykierungsmittel Antig lycation agents and counteract the formation of AGEs advanced glycation endproducts.

Compounds of the invention are useful as contrast reduction means, ie, they can brighten dark skin optionally or darken bright skin if necessary. The matrix for influencing and especially improving the staining behavior thereof by means of a pretreatment agent may be pretreated in a pretreatment step. Ein solches such a. Vorbehandlungsmittel kann basisch, sauer oder neutral sein, eine oxidative Wirkung, zum Beispiel durch Vorhandensein eines Oxidationsmittels wie Wasserstoffperoxid, aufweisen und gegebenenfalls Wasser enthalten.

Pretreatment agents may be basic, acidic or neutral, an oxidative effect, for example by the presence of an oxidizing agent such as hydrogen peroxide, exhibit and I behandelten Psoriasis Wasserstoffperoxid water. Typically, the pre-treatment step is carried out before the dyeing step.

Ein I behandelten Psoriasis Wasserstoffperoxid Gegenstand der Erfindung sind Zubereitungen, die zumindest eine Verbindung der Formel I, la, lb, I behandelten Psoriasis Wasserstoffperoxid oder ld, wie zuvor beschrieben, enthalten. Another object of the invention are preparations which contain at least one compound of formula I, la, lb, lc or ld as previously described. The compositions in this case comprise a cosmetically or dermatologically suitable vehicle and, depending on the desired property profile, optionally further suitable ingredients.

Handelt es sich um pharmazeutische Is it pharmaceutical. Preparations, the compositions in this case, a pharmaceutically acceptable carrier and optionally other active pharmaceutical ingredients. Handelt e sich um Medizinprodukte, so enthalten die Is e are medical devices, so include. Preparations a suitable for the medical support.

Topically applicable here means that the preparation is applied topically and locally, that is, the preparation must be suitable to be applied I behandelten Psoriasis Wasserstoffperoxid example to the skin can. Bevorzugt werden die topischen Zubereitungen als kosmetische oder dermatologische Zubereitung eingesetzt, insbesondere bevorzugt als kosmetische Zubereitung. Der Begriff Zubereitung wird gleichbedeutend auch als Mittel oder The term preparation is equivalent or as agent.

The formulations may be said necessary or optional constituents include or comprise, essentially or consist thereof. Alle Verbindungen oder Komponenten, I behandelten Psoriasis Wasserstoffperoxid in den All compounds or components which in the. Preparations can be used, are either known and commercially available or can be synthesized by known processes. In preferred embodiments, the at least one compound of formula I, la, lb, lc or ld with the defined or indicated as preferred substituents in the preparations of the invention typically in amounts of from 0.

Suitable excipients and active or excipients are described in detail in the next part. Bevorzugt ist die Zubereitung als Mehrkomponentensystem ausgestaltet, wobei zumindest eine Verbindung nach Formel I, wie zuvor beschrieben, als Entwicklungskomponente, zumindest eine Kupplungskomponente, optional ein Vorbehandlungsmittel, optional eine weitere Preferably, the preparation is designed as a multicomponent system, wherein at least one compound according to formula I, as described above, as a development component, at least one coupling component, optionally a pre-treatment agent, optionally a further.

Kupplungskomponente zumindest ein Oxidationsmittel, insbesondere Wasserstoffperoxid aufweist. Coupling component, at least one oxidizing agent, in particular comprising hydrogen peroxide. Geeignete Oxidationsfarbstoffkomponenten vom Entwicklertyp sind p- Phenylendiamin und dessen Derivate. I behandelten Psoriasis Wasserstoffperoxid oxidation dye components of the developer type are p-phenylenediamine and its derivatives. Weitere geeignete zweikernige Other suitable dinuclear.

Furthermore, it may be possible to use as the developer component is a p-aminophenol derivative or one of its physiologically tolerable salts. Preferred p-aminophenols, p-aminophenol, N-methyl-p-aminophenol, 4-aminomethyl-phenol, 4-aminofluorophenol, 2-hydroxymethylaminoaminophenol, 4-aminohydroxymethylphenol4-amino 2-hydroxyethoxy phenol, 4-aminomethylphenol, 4-aminohydroxymethylphenol, 4-aminomethoxymethyl-phenol, 4-amino aminomethylphenol, 4 amino 2-hydroxyethyl-aminomethyl phenol, 4-amino 1, 2-dihydroxyethyl phenol, 4-aminofluorophenol, 4-aminochlorophenol, 4-amino-26-dichlorophenol, 4-amino diethylaminomethyl - phenol and physiologically compatible salts.

Besonders bevorzugte Verbindungen sind p-Aminophenol, 4-Aminomethylphenol, 4-Amino aminomethylphenol, 4-Amino 1 ,2-dihydroxyethyl phenol und 4-Amino diethylaminomethyl phenol.

Particularly preferred compounds are para-aminophenol, 4-aminomethylphenol, 4-amino aminomethylphenol, 4-amino 1, 2-dihydroxyethyl phenol and 4-amino diethylaminomethyl -phenol. The developer component may be selected from o-aminophenol and its derivatives, such as 2-aminomethylphenol, 2-aminomethylphenol I behandelten Psoriasis Wasserstoffperoxid 2-aminochlorophenol.

Pyrimidin-Derivaten, Pyrazol-Derivaten, Pyrazolopyrimidin-Derivaten bzw. Pyrimidine derivatives, pyrazole derivatives, pyrazolopyrimidine derivatives and their physiologically compatible salts. Bevorzugte Pyrimidin-Derivate sind insbesondere die Verbindungen 2,4,5,6-Tetraaminopyrimidin, 4- Hydroxy-2,5,6-triaminopyrimidin, 2-Hydroxy-4,5,6-triaminopyrimidin, 2- Preferred pyrimidine derivatives are in particular the compounds 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6-triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, Dimethylamino-4,5,6-triaminopyrimidin, 2,4-Dihydroxy-5,6-diaminopyrimidin und 2,5,6-Triaminopyrimidin.

Dimethylamino-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopyrimidine and 2,5,6-triaminopyrimidine.

Die Entwicklerkomponenten werden bevorzugt in einer Menge von 0, bis 10 Gew. Verbindungen aus einer oder mehreren dieser Klassen. Check this out of one or more of these classes.

Weitere verwendbare Kupplerkomponenten, wie m-Aminophenole bzw. Weitere verwendbare Kupplerkomponeten, wie zB 3-Diaminobenzole bzw. Weitere verwendbare Kupplerkomponeten, wie zB o-Diaminobenzole bzw. Other useful Kupplerkomponeten, such as o-diaminobenzenes I behandelten Psoriasis Wasserstoffperoxid derivatives thereof, are preferably selected from at least one compound from the group which is formed from 3,4-diaminobenzoic acid and 2,3-diaminomethyl benzene, and their physiologically tolerable salts.

Resorcinmonomethylether, 2-Methylresorcin, 5-Methylresorcin, 2,5- Dimethylresorcin, 2-Chlorresorcin, 4-Chlorresorcin, Pyrogallol und 1,2,4- Trihydroxybenzol. Resorcinol monomethyl ether, 2-methylresorcinol, 5-methylresorcinol, 2,5-dimethylresorcinol, 2-chlororesorcinol, 4-chlororesorcinol, pyrogallol and 1,2,4-trihydroxybenzene.

As coupler component suitable naphthalene derivatives having at least one hydroxyl group are selected I behandelten Psoriasis Wasserstoffperoxid at least one compound of the group which is formed from 1-naphthol, 2-methylnaphthol, 2-hydroxymethylnaphthol, 2-hydroxyethylnaphthol, 13- dihydroxynaphthalene, 1, 5-dihydroxynaphthalene, 1, 6-dihydroxynaphthalene, 1, 7-dihydroxynaphthalene, 1, 8-dihydroxynaphthalene, 2,7-dihydroxynaphthalene and 2,3-dihydroxynaphthalene.

As Kupplerkomponente appropriate indole derivatives are chosen from 4-hydroxyindole, 6-hydroxyindole and 7-hydroxyindole and the physiologically acceptable salts. As Kupplerkomponente appropriate indoline I behandelten Psoriasis Wasserstoffperoxid preferably selected from 4-hydroxyindoline, 6-and 7-hydroxyindoline hydroxyindoline and physiologically acceptable salts thereof.

As Kupplerkomponente appropriate pyrimidine derivatives are selected from at least one of the group, which is formed from 4,6-diaminopyrimidine, 4-amino-2,6-dihydroxypyrirnidin, 2,4-diamino I behandelten Psoriasis Wasserstoffperoxid, 2,4,6-Trihydroxypyrimidin2-aminomethylpyrimidine, 2-aminohydroxymethylpyrimidine and 4,6-dihydroxymethylpyrimidine and its physiologically tolerable salts.

Die Kupplerkomponenten werden bevorzugt in einer Menge von 0, bis 10 Gew. In the described preparations containing at least one compound according to the invention according to formula I, I behandelten Psoriasis Wasserstoffperoxid, lb, lc or ld, also color pigments may further be included, wherein the layer structure of the pigments is not limited. Vorzugsweise sollte das Farbpigment bei Einssatz von 0,5 bis 5 Gew. Preferably, the color pigment in skin color should at one rate of 0.

Die Auswahl eines entsprechenden The selection of an appropriate. Pigment is familiar to those skilled. Below I behandelten Psoriasis Wasserstoffperoxid said UV filters are usually named according to the INCI nomenclature.

Particularly suitable for a combination are: PABA, Ethyl PABA, Ethyl dihydroxypropyl PABA, Ethylhexyl dimethyl PABA, z. ISP, Glyceryl PABA, PEG PABA, z. PABA, Ethyl PABA, Ethyl dihydroxypropyl PABA, Ethylhexyl dimethyl PABA, for example, sold under the name "Escalol " by the company ISP, Glyceryl PABA, PEG PABA, eg. Homosalate vertrieben unter dem Namen "Eusolex HS" von der Fa. Homo salads sold under the name "Eusolex HS" by the company Merck.

Symrise, Dipropylene glycol salicylate, z. Scher, TEA salicylate, z. Ethylhexyl salicylate, marketed for. Example, under the I behandelten Psoriasis Wasserstoffperoxid "Neo Heliopan OS" by the company. Symrise, Dipropylene glycol salicylate, for. Example, sold under the name "Dipsal" by the company. Scher, TEA salicylate, for.

Example, sold under the name "Neo Heliopan I behandelten Psoriasis Wasserstoffperoxid by the company. Ferner zB Methoxycrylen, vertrieben unter dem Namen Solastay I behandelten Psoriasis Wasserstoffperoxid von der Firma Hallstar.

Also, eg Methoxycrylen, sold under the I behandelten Psoriasis Wasserstoffperoxid Solastay S1 by the company Hallstar. Benzophenone-2, for example, sold I behandelten Psoriasis Wasserstoffperoxid the name "Uvinul D50"; Benzophenone-3 oder Oxybenzone, z. Benzophenone-3 or Oxybenzone, for example, sold under the name "Uvinul M40". Benzophenone-4, for example, sold under the name "Uvinul MS40"; Benzophenone-9, z. BASF, Benzophenone-5, Benzophe- none-6, z.

BASF, Benzophenone-5, benzophenone-6 none, z. American Cyanamid, Benzophenone n-hexyl 2- 4-diethylaminohydroxybenzoyl benzoate oder 2-Hydroxy methoxybenzophenon, vertrieben von der Fa. American Cyanamid, Benzophenone n-hexyl 2- 4-diethylaminohydroxybenzoyl benzoate, or 2- hydroxymethoxybenzophenone, sold by the company.

Chimex, 4-Methylbenzylidene- camphor, z. Chimex, Camphor benzalkonium methosulfate, z. Merck, Dinatrium phenyl dibenzimidazole tetrasulfonat, z. Merck, Disodium phenyl dibenzimidazole tetrasulfonate, z. Rhodia Chimie, Methylenebis benzo- triazolyl tetramethylbutylphenol in fester Form, z.

Fairmount Chemical, or in micronized form as an aqueous dispersion, z. Struktur von Mexoryl SBS: Structure of Mexoryl SBS: Menthyl anthranilate, for example, under the ertrieben. Namen "Neo Heliopan MA" von der Fa. Name "Neo Heliopan MA" by the company. Polyorganosiloxane enthaltend funktionelle benzalmalonate Gruppen, wie zB Polysilicone, z.

Sigma 3V und Mischungen dieses enthaltend. Sigma 3V and mixtures containing this. Pi erazinderivate wie beispielsweise die Verbindung Pi erazine derivatives such as the compound.

The compounds listed in the list should only as examples. Of course, other UV filters can be used. Ethylhexyl salicylate, Suitable organic UV-protective substances are preferably chosen from the following list: Phenylbenzimidazolesulfonic acid, Benzophenone-3, Benzophenone-4, Benzophenone-5, n-Hexyl 2- 4-diethylaminohydroxybenzoyl benzoate, 4-Methylbenzylidenecamphor, Terephthalylidenedicamphorsulfonic acid, Disodium phenyldibenzimidazoletetrasulfonate, Phenylbenzimidazolesulfonic acid, Benzophenone-3, Benzophenone-4, Benzophenone-5, n-Hexyl 2- 4-diethylaminohydroxybenzoyl benzoate, 4-Methylbenzylidenecamphor, Terephthalylidenedicamphorsulfonic acid, Disodium phenyldibenzimidazoletetrasulfonate.

Methylenebis benzotriazolyl tetramethylbutylphenol, Ethylhexyl Triazone, Diethylhexyl Butamido Triazone, Drometrizole trisiloxane, Polysilicone, 1 ,1-Dicarboxy 2,2-dimethylpropyl -4,4-diphenylbutadiene, 2,4-Bis[ dimethylpropyl benzoxazolyl 4-phenyl imino] 2-ethylhexyl imino- 1 ,3,5-triazine und Mischungen davon. Methylenebis benzotriazolyl tetramethylbutylphenol, Ethylhexyltriazone, diethylhexylbutamidotriazone Triazone, Drometrizole trisiloxane, polysilicone, 1, 1-dicarboxy 2.

Diese organischen UV-Filter werden in der Regel in einer Menge von 0,01 Gewichtsprozenten bis 20 Gewichtsprozenten, vorzugsweise 1 Gew.

These organic UV filters are usually in an amount of 0. These combinations with particulate UV filters are possible I behandelten Psoriasis Wasserstoffperoxid as powder I behandelten Psoriasis Wasserstoffperoxid as a dispersion or paste of the following types. Hierbei sind sowohl solche aus der Gruppe der Titandioxide wie zB Here, both those from the group of titanium dioxides, such as.

Phospholipids, sodium, potassium, I behandelten Psoriasis Wasserstoffperoxid, Dukan Herpes Juckreiz Behandlung or aluminum salts of fatty acids, polyethylenes, silicones, proteins collagen or elastin particularlyalkanolamines, silicon dioxide, aluminum oxide, other metal oxides, phosphates, such as sodium hexametaphosphate or glycerol.

Preferably used particulate UV filters are: Tayca; - Untreated titanium dioxides, such as the products Micro Titanium Dioxide MT B Tayca. Titandioxd P25 der Fa. Degussa, Titanium dioxide in P Uniqema, or the product "Tioveil Fin" Fa.

Tayca, Eusolex T der Firma Merck. Tayca, Eisenstearate aftertreatment such as the product "Micro Titanium Dioxide MT 00 F" from the company. Aluminiumoxid und Silicon Nachbehandlung wie zB das Produkt Alumina and silicone post-treatment such as the product. Tayca, - Nachbehandelte mikronisierte Titandioxide mit Natrumhexameta- phosphate, wie zB das Produkt "Microtita nium Dioxide MT W" der Fa.

Aftertreated micronised titanium dioxides with phosphates Natrumhexameta- such as the product "Microtita nium Dioxide MT W" Tayca. Die zur Kombination einzusetzenden behandelten mikronisierten The selected combination of treated micronized. Titanium dioxide can also be treated with: Octyltrimethoxysilane; Octyltrimethoxysilane; wie zB das Produkt Tego Sun T der Fa.

Degussa, such as the product Tego Sun Psoriasis polisorb Bewertungen Siliciumdioxid; silica; wie zB das Produkt Parsol TX der Fa. Aluminium und Glycerin; Aluminum and glycerol; wie zB das Produkt UV-Titan der Fa. Sachtleben, Aluminum and silicone oils, such as the product UV-Titan M Fa.

Natriumhexamethaphosphat und Polyvinylpyrrolidon, Sodium hexametaphosphate and polyvinyl pyrrolidone. Polydimethylsiloxane, wie zB das Produkt Cardre UF Ti02SI3" der Fa.

Cardre, Polydimethylsiloxanes, such as the product cardre Ti02SI3 UF "from. Polydimethylhydrogensiloxane, wie zB das Produkt Microtitanium Dioxide USP Grade Hydrophobie" der Fa. Polydimethylhydrogensiloxanes, I behandelten Psoriasis Wasserstoffperoxid as the product Microtitanium Dioxide USP Grade learn more here "of the company. Ferner kann auch die Kombination mit folgenden Produkten vorteilhaft sein: Furthermore, the combination with the following products can be advantageous: Unbehandelte Zinkoxide wie z.

BASF Sunsmart article source, Nanox der Fa. Elementis Untreated zinc oxides such. As the product Z-Cote of Fa. BASF SunSmart Nanox the Fa. Nachbehandelte Zinkoxide wie zB die folgenden Produkte: Nanophase Technologies o Nanogard Zinc Oxide FN Fa. Fuji Pigment ZnO nachbehandelt mit o "Fuji ZNO-SMS" I behandelten Psoriasis Wasserstoffperoxid. Fuji Pigment ZnO treated with.

Siliciumdioxid und Polymethylsilesquioxan ; Silica and Polymethylsilesquioxan. Bezeichnung Nanogar der Fa. Designation Nanogar the Fa. Exemplary mixtures of different metal oxides, such as titanium dioxide and cerium oxide can with and without post-treatment, such as the product Sunveil A Fa.

In addition, mixtures of alumina, silica and titanium dioxide Silikonnachbehandelten. Zinc oxide mixtures such as. Sachtleben used in combination with the inventive UV stabilizers. Diese anorganischen UV-Filter werden in der Regel in einer Menge von 0,1 Gewichtsprozenten bis 25 Gewichtsprozenten, vorzugsweise 2 Gew.

These inorganic UV filters are usually in an amount of 0. Einwirkungen der UV-Strahlung optimiert werden. Effects of UV radiation can be optimized. All the said UV filters can also be employed in encapsulated form. Insbesondere ist es von Vorteil organische UV-Filter in In particular, it is advantageous organic UV filters in. Daher kann es bevorzugt sein, wenn ein oder mehrere der oben genannten UV-Filter in verkapselter Form vorliegen.

Therefore, it may be preferred if one or more of the above-mentioned UV filters to be in encapsulated form. It is advantageous if the capsules are so small I behandelten Psoriasis Wasserstoffperoxid they can not be observed with the naked eye. Zur Erzielung der og Effekte ist es weiterhin I behandelten Psoriasis Wasserstoffperoxid, dass die Kapseln hinreichend stabil sind und den verkapselten Wirkstoff UV-Filter I behandelten Psoriasis Wasserstoffperoxid oder nur in geringem Umfang an die Umgebung abgeben.

To achieve the above-mentioned effects, it is still necessary that the capsules to be sufficiently stable and the encapsulated active ingredient UV filter or submit only to a small extent to was mit Psoriasis Kopf essen environment. Antioxidantien, Anti-aging-Wirkstoffen, Anti-Cellulite Wirkstoffen, Antioxidants, anti-aging agents, anti-cellulite agents. The protective effect of preparations against oxidative stress I behandelten Psoriasis Wasserstoffperoxid against the effect of free radicals can be improved if the compositions comprise one or more antioxidants, which is the expert to no difficulty suitable fast or delayed-action antioxidants select.

Geeignete Antioxidantien sind auch Verbindungen der Formeln A oder B Suitable antioxidants are also compounds of the formulas A or B. XO oder NH, X is O or NH. R 2 lineares oder verzweigtes Alkyl mit 1 bis 30 C-Atomen, R 2 is linear or branched alkyl having 1 to 30 carbon atoms. R 3 lineares oder verzweigtes Alkyl mit 1 bis 20 C-Atomen, R 3 is linear or branched alkyl having 1 to 20 carbon atoms.

R 5 H oder lineares I behandelten Psoriasis Wasserstoffperoxid verzweigtes Alkyl mit 1 bis 8 C-Atomen oder lineares oder verzweigtes Alkoxy mit 1 bis 8 C-Atomen und R 5 is H or linear or branched alkyl having 1 to 8 carbon atoms or linear or branched alkoxy having 1 to 8 C atoms and. Further, the combination with 2- 4-hydroxymethoxy-benzylidene - malonic acid to isopropyl or 2- 4-hydroxymethoxy-benzyl - malonate-to-isopropyl hydrogenated diisopropyl vanilidene malonate preferred.

The same applies to corresponding bis-ethyl ester. Mixtures of antioxidants are likewise suitable for use in the cosmetic preparations according to the invention. Derartige Antioxidantien werden mit den Antioxidants I behandelten Psoriasis Wasserstoffperoxid the. Compounds of the invention in such compositions, typically in weight ratios in the range of Among the phenols which can be used according I behandelten Psoriasis Wasserstoffperoxid the invention, some of which are naturally occurring polyphenols for applications in the pharmaceutical, cosmetic or nutrition sector are particularly interesting.

For example, which are principally known as plant dyes, flavonoids or bioflavonoids, frequently have an antioxidant potential. Zubereitungen, sind vorzugsweise sogenannte kompatible Solute. Preparations are preferably so-called compatible solutes. Es handelt sich dabei um Substanzen, die an der Osmoregulation von Learn more here are substances which by in osmoregulation. Plants or microorganisms are involved and can be isolated from these organisms.

Unter den Oberbegriff kompatible Solute werden dabei auch die in der Deutschen Patentanmeldung DE-A beschriebenen Osmolyte gefasst.

The generic I behandelten Psoriasis Wasserstoffperoxid compatible solutes here also encompasses the osmolytes described in German patent application DE-A are taken. Suitable osmolytes are, for example, the polyols, methylamine compounds and amino acids and respective precursors thereof. Als Osmolyte werden im Sinne der Deutschen Osmolytes within the meaning of the German.

Precursors of these substances are, for example, glucose, glucose polymers, phosphatidylcholine, phosphatidylinositol, inorganic phosphates, proteins, peptides and polyamino acids.

Verbindungen, die durch metabolische Schritte in Osmolyte umgewandelt werden. Example, compounds which are converted by metabolic steps in osmolytes. Here are the pyrimidinecarboxylic particular ectoine S - 4,5,6-tetrahydromethylpyrimidine-carboxylic and hydroxyectoin S, S -1, 4,5,6-tetrahydro hydroxymethylpyrimidinecarboxylic acid and I behandelten Psoriasis Wasserstoffperoxid thereof to name. Furthermore, link according to the invention may comprise at least one self as a further ingredient.

Advantageous self can be used, among other things: Ganz besonders bevorzugt ist das 1 ,3-Dihydroxyaceton, Erythrulose oder deren Very particularly preferably, the 1, 3-dihydroxyacetone, erythrulose or their. The preparations can also contain one or more other skin lightening agents, or synonymously Depigmentierungswirkstoffe. Skin lightening agents may be any known to those skilled agents principle. Maulbeerbaumextract, agnesium-ascorbyl-phosphat, Maulbeerbaumextract, agnesium-ascorbyl phosphate.

Substanzen wie unter WO beschrieben. The preparations may comprise vitamins as further ingredients. Pantothenic acid and biotin. Vitamins with the flavonoid-containing I behandelten Psoriasis Wasserstoffperoxid or compositions usually added in cosmetic application in ranges of 0.

Nutritional applications are based on the respective recommended vitamin requirements. Die beschriebenen Retinoide sind gleichzeitig auch wirksame Anti-Cellulite- Wirkstoffe. The retinoids described are simultaneously also effective anti-cellulite agents. Ein ebenfalls bekannter Anti-Cellulite-Wirkstoff ist Koffein. A well-known anti-cellulite active ingredient is caffeine. The aforementioned constituents of the formulation can be incorporated in the usual manner, using techniques that are well known in the art.

You can be as solid sticks or here be formulated as an aerosol. Suitable for internal use are administration forms such as capsules, coated tablets, powders, tablet solutions or solutions are suitable. Als Anwendungsform der einzusetzenden Zubereitungen seien zB Use forms of the preparations to be used are for example.

Preferred assistants originate from the group of preservatives, stabilizers, solubilisers, colorants and odor. Cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide or mixtures of these substances. Powders and sprays can contain the customary excipients, click to see more example lactose, talc, silica, aluminum hydroxide, calcium silicate and polyamide powder or mixtures of these substances.

Auch Druckluft ist vorteilhaft zu verwenden. Compressed air can also be used advantageously. Peanut oil, corn oil, olive oil, castor oil and sesame oil, glycerol fatty esters, polyethylene glycols and fatty acid esters of sorbitan or mixtures of these substances.

A preferred solubilizing agent is generally 2-isopropylmethyl-cyclohexanecarbonyl-D-alanine. Suspensions may comprise the customary excipients such as liquid diluents, for example water, ethanol or propylene glycol, suspending agents, eg ethoxylated isostearyl alcohols, polyoxyethylene sorbitol esters and polyoxyethylene ethylensorbitanester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar and tragacanth or mixtures of these substances.

Soaps may comprise the customary excipients, such as alkali metal salts of fatty acids, salts of fatty acid monoesters, fatty acid protein hydrolysates, isethionates, lanolin, fatty alcohol, vegetable oils, plant extracts, glycerol, sugars or mixtures of these substances. Vegetable oils and oily plant extracts, paraffin oils, lanolin oils or mixtures of these substances.

Weitere typische kosmetische Anwendungsformen sind auch Lippenstifte, Lippenpflegestifte, Puder- Emulsions- und Wachs-Make up sowie Further typical cosmetic application forms are also lipsticks, lip-care sticks, powder emulsion and wax make-up and. Sunscreen, pre-sun and after-sun preparations. The preferred preparation forms include, in particular, emulsions. Emulsionen I behandelten Psoriasis Wasserstoffperoxid vorteilhaft und enthalten z.

Emulsions are advantageous and comprise, for. Example, the fats, oils, waxes and other fatty substances, as well as water and an emulsifier, as usually used for a composition of this I behandelten Psoriasis Wasserstoffperoxid. The lipid phase can advantageously be chosen from the following substances: Diphenylpolysiloxane sowie Mischformen daraus.

Diphenylpolysiloxanes and mixed forms I behandelten Psoriasis Wasserstoffperoxid. Isopropylmyristat, Isopropylpalmitat, Isopropylstearat, Eines Augen in Kindes Psoriasis den, n-Butylstearat, n-Hexyllaurat, n-Decyloleat, Isooctylstearat, Isononylstearat, Isononylisononanoat, 2-Ethylhexylpalmitat, 2-Ethylhexyllaurat, Isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, Isononylstearat, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate.

The fatty acid triglycerides can, for example, advantageously be chosen from the group of synthetic, semi-synthetic and natural oils, eg. Any mixtures of such oil and wax components are advantageously for the purposes of the present invention. It may also be advantageous to I behandelten Psoriasis Wasserstoffperoxid waxes, for example cetyl palmitate, I behandelten Psoriasis Wasserstoffperoxid the sole lipid component of the oil phase.

Siliciumdioxid, Aluminiumsilikate, Polysaccharide bzw. Silica, aluminum silicates, polysaccharides and derivatives thereof, eg hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of Carbopols, for example Carbopol grades,respectively singly or in combination. In particular, mixtures of the abovementioned solvents are used. Example, the fats, oils, waxes and other fatty substances, as well as water and an emulsifier, as usually used for a formulation of this type.

In a preferred embodiment, the preparations employed comprise hydrophilic surfactants. The hydrophilic surfactants are preferably selected from the group consisting of alkyl glucosides, acyl lactylates, betaines and coconut amphoacetates. The cosmetic and dermatological preparations can be in various forms. So they can eg. Es ist auch vorteilhaft, Ectoine in verkapselter Form darzureichen, dann Kürbiskernöl Psoriasis created. Collagen matrices and other conventional encapsulation materials, for example.

Example as cellulose, in gelatine, wax matrices or liposomally encapsulated. In particular, wax matrices, as described in DE-A 08have proven favorable. Preference is given to emulsions. Emulsifiers also be lower or higher. It is advantageous to select the fatty alcohol ethoxylates from the group of ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols cetearyl alcohols. It is furthermore advantageous to select the fatty acid ethoxylates from the following group: Polyethylenglycol 20 stearat, Polyethylenglycol 21 stearat, Polyethylene glycol 20 stearate, polyethylene glycol 21 stearate.

Polyethylenglycol 22 stearat, Polyethylenglycol 23 stearat, Polyethylene glycol 22 stearate, polyethylene glycol 23 stearate. Polyethylenglycol 24 stearat, Polyethylenglycol 25 stearat, Polyethylene glycol 24 stearate, polyethylene glycol 25 stearate. I behandelten Psoriasis Wasserstoffperoxid 12 isostearat, Polyethylenglycol 13 isostearat, Polyethylene glycol 12 isostearate, polyethylene glycol 13 isostearate. Polyethylenglycol 14 isostearat, Polyethylenglycol 15 isostearat, Polyethylene glycol 14 isostearate, polyethylene glycol 15 isostearate.

Polyethylenglycol 16 isostearat, Polyethylenglycol 17 isostearat, Polyethylene glycol 16 isostearate, polyethylene glycol 17 isostearate. Polyethylenglycol 18 isostearat, Polyethylenglycol 19 isostearat, Polyethylene glycol 18 isostearate, polyethylene glycol 19 isostearate. Polyethylenglycol 20 isostearat, Polyethylenglycol 21 isostearat, Polyethylene glycol 20 isostearate, polyethylene glycol 21 isostearate.

Polyethylenglycol 22 isostearat, Polyethylenglycol 23 isostearat, Polyethylene glycol 22 isostearate, polyethylene glycol 23 isostearate. Polyethylenglycol 24 isostearat, Polyethylenglycol 25 isostearat, Polyethylenglycol 12 oleat, Polyethylenglycol 13 oleat, Polyethylene glycol 24 isostearate, polyethylene glycol 25 isostearate, polyethylene glycol 12 oleate, polyethylene I behandelten Psoriasis Wasserstoffperoxid 13 oleate.

Polyethylenglycol 14 oleat, Polyethylenglycol 15 oleat, Polyethylene glycol 14 oleate, polyethylene glycol 15 oleate. Polyethylenglycol 16 oleat, Polyethylenglycol 17 oleat, Polyethylene glycol 16 oleate, polyethylene glycol 17 oleate. Polyethylenglycol 18 auf der, Polyethylenglycol 19 oleat, Polyethylene glycol 18 oleate, polyethylene glycol 19 oleate.

Polyethylene glycol 20 oleate. Ais ethoxylated alkyl ether or salt thereof which can advantageously be used the sodium laureth carboxylate. Als Alkylethersulfat kann Natrium Laurethsulfat vorteilhaft verwendet werden. An alkyl ether sodium laureth can be used advantageously.

Als ethoxyliertes Cholesterinderivat kann vorteilhaft Polyethylenglycol 30 Cholesterylether verwendet werden. An ethoxylated cholesterol derivative which can advantageously be used is polyethylene glycol 30 cholesteryl.

Polyethylene glycol 25 soya sterol has proven itself. It is likewise I behandelten Psoriasis Wasserstoffperoxid to select the sorbitan esters from the group polyethylene glycol 20 sorbitan, polyethylene glycol 20 sorbitan monostearate, polyethylene glycol 20 sorbitan, polyethylene glycol 20 Sorbian tanmonopalmitat, polyethylene glycol 20 sorbitan to choose. Diglycerylmonostearat, Diglycerylmonoisostearat, Propylenglycol- monostearat, Propylenglycolmonoisostearat, Propylenglycolmonocaprylat, Propylenglycolmonolaurat, Sorbitanmonoisostearat, Sorbitanmonolaurat, Sorbitanmonocaprylat, Sorbitanmonoisooleat, Saccharosedistearat, Cetyl- alkohol, Stearylalkohol, Arachidylalkohol, Behenylalkohol, Isobehenyl- alkohol, Selachylalkohol, Chimylalkohol, Polyethylenglycol 2 stearylether Steareth-2Glycerylmonolaurat, Glycerylmonocaprinat, Glycerylmono- caprylat oder PEGdipolyhydroxystearat.

Diglycerylmonostearat, Diglycerylmonoisostearat, propylene glycol monostearate, Propylenglycolmonoisostearat, Propylenglycolmonocaprylat, propylene glycol, sorbitan, sorbitan Sorbitanmonocaprylat, Sorbitanmonoisooleat, sucrose distearate, cetyl alcohol, stearyl alcohol, arachidyl, behenyl, Isobehenyl- alcohol, selachyl, chimyl, polyethylene glycol 2 stearyl steareth 2glyceryl monolaurate, Glycerylmonocaprinat, glyceryl caprylate or PEG dipolyhydroxystearate.

Verdickungsmittel, weichmachende Mittel, Befeuchtungsmittel, Thickeners, emollients, humectants. Man kann als Dispersions- bzw. One can use it as a dispersant or solubiliser an oil, wax or other fatty substance, a lower monoalcohol or lower polyol or mixtures thereof. The particularly preferred monoalcohols or polyols include ethanol, i-propanol, propylene glycol, glycerol and sorbitol. A preferred embodiment of the invention is an emulsion in the form of a protective cream or milk and contains, for example fatty alcohols, fatty acids, fatty acid esters, in particular triglycerides of fatty acids, lanolin, natural and synthetic oils or waxes and emulsifiers in presence of water.

Die Zubereitung kann auch als alkoholisches Gel vorliegen, welches einen oder mehrere Niedrigalkohole oder -polyole, wie Ethanol, Propylenglykol oder Glycerin, und ein Verdickungsmittel, wie Kieselerde umfasst. The preparation can also be present as an alcoholic gel which comprises one or more lower alcohols or polyols such as ethanol, propylene glycol or glycerol, and a thickener such as silica.

The solid sticks consist of natural or synthetic I behandelten Psoriasis Wasserstoffperoxid and oils, fatty alcohols, fatty acids, fatty acid see more, lanolin and other fatty substances. Is a preparation formulated as an aerosol, one uses in general, the customary propellants, such as alkanes, fluoroalkanes and chlorofluoroalkanes, preferably alkanes. Even without further comments, it is assumed that an expert can utilize the above description in the broadest scope.

I behandelten Psoriasis Wasserstoffperoxid complete disclosure of all mentioned above and below applications and publications are incorporated by reference into this application. Examples of preparations include explicitly the disclosure of the I behandelten Psoriasis Wasserstoffperoxid and can therefore be used as features. Further important features and advantages of the invention will be apparent from the dependent claims and from the examples.

Alleinstellung verwendbar sind, ohne den Rahmen der vorliegenden are their own, without the context of the present. Preferred embodiments of the invention I behandelten Psoriasis Wasserstoffperoxid illustrated in the examples, and are explained in detail in the following description, without restricting the scope of the present invention.

Preparation of 4-phenylazo-benzoic acidmethlyoxo-4H-pyranyl ester. The red suspension a solution of 5,70g Die Reaktionsmischung dickt ein. The reaction mixture thickens a. The mixture is stirred for 48 h at room temperature RT. The filter cake is stirred with 50mL THF and again aspirated. The combined washings are concentrated to about mL. It can be obtained at RT overnight red crystals that still washed with a little ethyl acetate and then i.

Preparation of 4- 4-dimethylamino-phenylazo benzoic acidmethyloxo-4H-pyran-yl-ester. Dann wird aus Isopropanol umkristallisiert. Then, it is recrystallized from isopropanol. After exhausting the residue with 50 mL THF is stirred and sucked the solid, then the solid was recrystallized again from mL acetonitrile and isopropanol as required.

Es werden insgesamt mg erhalten. It will receive a total of mg. Dimethylamino styryl pyridinium bromide, 0,40g 3,18 mmol 3-hydroxymethylpyranone and 0. To the red suspension is 0.

It is filtered under vacuum and the residue washed I behandelten Psoriasis Wasserstoffperoxid 10mL THF. Es wird im Vakuum filtriert und mit Essigester nachgewaschen. It is filtered under vacuum and washed with ethyl acetate. Synthese von 6-[6- 3-Dimethylamino-propylamino -1 ,3-dioxo-1 H,3H- benzo[de]isoquinolinyl]-hexanoic acid 2-methyloxo-4H-pyranyl ester 4 Synthesis of 6- [6- 3-dimethylamino-propylamino -1, 3-dioxo-1 H, 3H-benzo [de] isoquinolineyl] -hexanoic acid 2-methyloxo-4H-pyran yl ester 4.

Adam et al, Tetrahedron: Asymmetry74 10zur Verbindung 2 umgesetzt wird, die entsprechend nach der in US A beschriebenen Methode zur Verbindung 3 aminiert wird. Compound 3 is prepared by reacting commercially available 6-chloro-benzo [de] isochromene-1, 3-dione according to W. Adam, et al, Tetrahedron: Asymmetry74 10to give the compound 2, which is aminated according to the procedure described in US A method for connection. I behandelten Psoriasis Wasserstoffperoxid reaction of the free acid of the compound 3 with 3-hydroxymethylpyranone carried out analogously to example 1.

Preparation of 4-phenylazo-benzoic acid 1, 2-dimethyloxo-1, 4-dihydro-pyridinyl ester. Detection of protein I behandelten Psoriasis Wasserstoffperoxid lysine model: The substances of Example 1 and 2 are I behandelten Psoriasis Wasserstoffperoxid weighed to 0mg in a 10 mL volumetric flask and 5 mL tetrahydrofuran THF. The flask is then filled with a lysine solution in distilled water up to the mark.

Nach 1 h und nach 24 h werden Proben gezogen. After 1 h and after 24 h samples are drawn. Davon pipettiert man je 5 pL mit einer Mikropipette auf die Startzone einer HPTLC Silica gel 60 F Platte Merck Art. Of Pipette each 5 pL with a micropipette on the starting line of a HPTLC silica gel 60 F plate Merck Art.

Nach Entwicklung detektiert man in einem CAMAG ATS4 bei nm und nm und ermittelt die Rf-Werte. After development is detected in a CAMAG ATS4 at nm and nm and determines the Rf values.

Substanz 1 besitzt einen Rf-Wert von 0,62, Substanz 2 von 0, Bereits nach 1h in Kombination mit Lysin sind beide Substanzen deutlich, nach 24h komplett, in einer Proteinreaktion mit Lysin umgesetzt. After 1 h in combination with lysine, both substances are clear after 24 completely, converted into a protein reaction with lysine.

Ausgangssubstanzen sind nicht mehr detektierbar. Starting materials are no longer detectable. In contrast, Maillard products have emerged, which are detected in the start zone of the HPTLC plate. Der pH-Wert des Http://feuervogel-online.de/psoriasis-im-jahr-2015.php ist alkalisch. The pH of the water is alkaline. After 24h, the wool taken out and thoroughly rinsed with tap water.

Haarfarbe aus verschiedenen Komponenten: Hair color of several components: Tocopherol, linalool, geraniol, Disodium EDTA, Fragrance, ascorbic acid, alcohol denat.

Aqua, hydrogen peroxide, cetearyl alcohol, PPGbuteth, petrolatum, laureth-2, more info cetearyl sulfate, salicylic acid, disodium phosphate, phosphoric acid, etidronic acid. Aqua, hydrogen peroxide, cetearyl alcohol, PPGButeth, petrolatum, I behandelten Psoriasis Wasserstoffperoxid, sodium cetearyl sulfate, salicylic acid, disodium phosphate, phosphoric acid, etidronic acid.

For hair dyeing is preferred to proceed in the following order: First, the hair is pretreated with component C, Subsequently, the components B and C are mixed and applied I behandelten Psoriasis Wasserstoffperoxid the hair. After coloring component D is applied.

Haarfarbe aus verschiedenen Komponenten. Hair color of different components "Konponente A.: Tocopherol, linalool, geraniol, Disodium EDTA, Fragrance, Toluene-2,5-diamine sulfate, ascorbic acid, alcohol denat.

For all example formulations of preparations that they can be produced optionally free of UV filters. Pelemor BIP, Arlasolv DMI und Emulgatoren werden vorgelegt. Pelemor GDP, Arlasolv DMI and emulsifiers are presented. The remaining oil phase ingredients are added and mixed homogeneously. While stirring source set with citric acid to pH aqueous phase is emulsified.

The mixture is then homogenized. The emulsions can be prepared under mild conditions at room temperature. Wasserfestes Sonnenschutzspray mit Auftragskontrolle Example D: SYNDEMICS Yak Psoriasis lіkuvati system sunscreen spray with job control.

The components of phase A are combined at room temperature and stirred until a clear solution or homogeneous I behandelten Psoriasis Wasserstoffperoxid present.

Then Phase B is mixed and added with stirring to Phase B. Stirring is continued until ultimately there is the homogeneous product. Pump Spray Hair Dye.

Phase A predissolved until a clear solution is present. While stirring, phase B to phase A. Phase C I behandelten Psoriasis Wasserstoffperoxid and add to the residue, stir until a homogeneous mixture has formed.

WVO-Emulsionen Emulsion ABCDEF Example F: WVO emulsions Emulsion ABCDEF. Polyglyceryl 3 5 3 Polyglyceryl-2 3 5 3. PEG Dipolyhydroxystearat 2 3 4 5 PEG dipolyhydroxystearate 2 3 4 5. Glycin 0,3 0,3 0,5 0,4 Glycine 0. Alkohol 5 2 5 4 Alcohol 5 2 5 4. Magnesiumsulfat 0,2 0,3 0,3 0,4 0,5 0,2 Magnesium sulfate 0. Ci 2 Alkyl Benzoat 5 3 5 C 2 alkyl benzoate 5 3 5. C 13 Alkyl Tartrat 2 C 13 alkyl tartrate 2. Dicaprylyl Ether 2 I behandelten Psoriasis Wasserstoffperoxid Ether 2.

Octyldodecanol 2 Octyldodecanol 2. Dicaprylcaprat 2 2 2 Dicaprylcaprat 2 2 2. Cyclomethicon 5 5 10 Cyclomethicone 5 5 Dimethicon 5 dimethicone 5. Isohexadecan 1 isohexadecane 1. Butylenglycol I behandelten Psoriasis Wasserstoffperoxid 8 3 Butylene glycol 5 8 3. Propylenglykol 1 5 3 Propylene glycol 1 5 3. Titandioxid 5 6 4 4 Titanium dioxide 5 I behandelten Psoriasis Wasserstoffperoxid 4 4. Zinkoxid 5 zinc oxide 5. Bis-Ethylhexyloxyphenol 3 3 2 Up-Ethylhexyloxyphenol 3 3 2.

Methoxyphenyltriazin Emulsion AB c DEF Methoxyphenyltriazin emulsion AB c DEF. Ethylhexyltriazon 4,5 3 3 Ethylhexyltriazon 4. Diethylhexylbutamidotriazon 1 ,5 4 Diethylhexylbutamidotriazon 1, 5 4. Butyl Methoxydibenzoylmethan 2 3 4 1 3 Butyl methoxydibenzoylmethane 2 3 4 1 3. Ethylhexylmethoxycinnamat 7 5 Ethylhexylmethoxycinnamate 7 5. Farbstoff nach Beispiel 2 4,0 0,5 1 ,5 0,5 A dye according to Example 2 4. Taurin 0,1 0,5 0,2 Taurine 0. Vitamin E Acetat 0,2 02 0,3 0,1 0,5 Vitamin E acetate 0.

C8-C16 Alkylpolyglycosid 1 C8-C16 alkylpolyglycoside 1. Perfume, preservative qs qs qs qsqs. Natriumhydroxid qsqsqsqs qsqs Sodium qsqsqsqs qsqs. Wasser ad ,0 ad ,0 ad ,0 ad ,0 ad ad Water Haarpflegeformulierung EXAMPLE G hair care formulation.

Gehalt in g Komponente per g Formulierung Content in g per g I behandelten Psoriasis Wasserstoffperoxid component. Komponente ABCDEF component ABCDEF. Farbstoff nach Beispiel 1 0,10 0,25 0,50 1A dye according to Example 1 0. Farbstoff nach Beispiel 2 0,50 1 ,00 1 ,50 2,00 2,50 3,00 A dye according to Example 2 0. Komponente Http://feuervogel-online.de/behandlung-von-typ-1-diabetes-pruritus.php c DEF Component AB c DEF.

Glycyrrhetinic acid 0 0 0. N-undecylenoyl-L-phenylalanine 0 0 0 0 1. N-acetyl glucosamine 0 0 0 0 0 2. Isopropyl N-Iaurosylsarcosinate 0 0 5. Water to g Water to g. TOTAL Total Komponente GHI component GHI.

Farbstoff nach Beispiel 1, 2, 3 oder 4 oder A dye according to Example 1, 2, 3 or 4 or. Farbstoffkombination aus den Farbstoffen 0. Cetyl pyridinium Chloride 0. Ascorbyl glycoside I behandelten Psoriasis Wasserstoffperoxid 0 2. Polyquaternium 37 0 0 0 Polyquaternium 37 0 0 0. Komponente GH 1 Component GH 1. Water to g to to to Water to g to to to TOTAL TOTAL Emulsion ABCDEF emulsion ABCDEF.

Glyceryl Stearat Citrat 2,5 2 3 Glyceryl stearate citrate 2. Sorbitanstearat 0,5 2 1 ,5 2 Sorbitan stearate 0. Polyglyceryl-3 Methylglycose Polyglyceryl-3 methylglycose. Distearat 2,5 Medicine, Psoriasis Creme Preis Tage 3 Distearate 2. Polyglyceryl-2 0,8 0,5 Emulsion ABCDEF Polyglyceryl-2 0. Cetearylalkohol 1 cetearyl 1.

Stearylalkohol 2 2 Stearyl 2 2. Cetylalkohol 1 3 Cetyl alcohol 1 3. Crosspolymer 0,1 Crosspolymer 0. Carbomer 0,2 0,3 0,2 Carbomer 0. Xanthan Gum 0,4 0,2 0,2 0,3 0,4 Xanthan Gum 0. C 2 Alkyl Benzoat 5 3 5 C 2 alkyl benzoate 5 3 5. Propylengykol 1 5 3 Propylene glycol, 1 5 3. Titandioxid 5 2 Titanium dioxide 5 2. Merocyanin an Gelatine Merocyanine of gelatin. Benzotriazol an Gelatine Benzotriazole of gelatin. C8-C16 Alkylpolyglycosid 1 0,6 C8-C16 alkylpolyglycoside 1 0.

Homosalat 5 1 Homosalate 5 1. Benzophenon-3 0,5 1 Benzophenone-3 0. Octylsalicylat 5 5 2 Octyl salicylate 5 5 2. Octocrylen 2 3 1 Octocrylene 2 3 1. Farbstoff nach Beispiel 1 0,1 0,2 0,3 0,4 0,5 1 ,0 A dye according to Example 1 0. Farbstoff nach Beispiel 2 0,1 0,2 0,3 0,4 0,5 1 ,0 A dye according to Example 2 I behandelten Psoriasis Wasserstoffperoxid. Dihydroxyacetat 4 Dihydroxyacetat 4.

Vitamin E Acetat 0,2 0,2 0,3 0,1 0,5 Vitamin E acetate 0. Na 2 H 2 EDTA 0,1 0,1 0,2. Konservierungsmittel qsqs Preservatives qsqs. Natriumhydroxid qsqsqsqsqsqs sodium qsqsqsqsqsqs.

Wasser ad ad ,0 ad ,0 ad ,0 ad ,0 ad ,0Water ad Emulsion GH 1 KLM Emulsion GH 1 KLM. Ceteareth 1 1 ,5 1 Ceteareth 1 1, 5 1. Sorbitanstearat 0,5 0,5 Sorbitan 0. Glyceryl Stearat SE 1 1 1 ,5 Glyceryl stearate SE 1 1 I behandelten Psoriasis Wasserstoffperoxid 5. Stearylalkohol 1 ,5 Stearyl alcohol 1, 5. Cetylalkohol 0,5 2 Cetyl alcohol 0. Carbomer 0,3 Carbomer 0. Xanthan Gurrt 0,4 0,4 Xanthan coos 0. C Alkyl Benzoat 5 3 5 C alkyl benzoate 5 3 5.

Diethylhexylnaphthalat 2 diethylhexyl 2. Isohexadecan 5 Emulsion GH 1 KLM Isohexadecane 5 Emulsion GH 1 KLM. Propylenglykol 4 Propylene glycol 4. Titandioxid 5 3 2 Titanium dioxide 5 3 2. Farbstoff nach Beispiel 1 A dye according to Example 1. Farbstoff nach Beispiel 3 0,5 3,0 1 ,0 0,5 A dye according to Example 3 0. Kreatinin 0,1 0,01 0,05 Creatinine 0. Kreatin 0,5 0,2 0,1 Creatine 0.

Vitamin E Acetat 0,2 0,5 0,5 0,5 Vitamin E acetate 0. Konservierungsmittel qsqsqs Preservatives qsqsqs. Pigmentfarbstoffe qsqsqsqsqsqs Pigments qsqsqsqsqsqs. Wasser ad ,0 ad ,0 ad ,0 ad ,0 ad ,0 ad ,0 Water Emulsion NOPQRS emulsion NOPQRS. Glycerylstearat SE 2 2 Emulsion NOPQRS Glyceryl stearate SE 2 2 emulsion NOPQRS.

Glycerylstearat 2 2 Glyceryl 2 2. PEG Stearat 2 1 PEG Stearate 2 1. PEG Stearat 2,5 1 PEG stearate 2. Ceteareth 2,6 Ceteareth I behandelten Psoriasis Wasserstoffperoxid. Natrium Cetyl Phosphate 2 Sodium I behandelten Psoriasis Wasserstoffperoxid Phosphate 2.

Glyceryl Stearat, Ceteareth- 5,4 12, Ceteareth, Cetearyl Glyceryl stearate, Ceteareth- 5. Alcohol, Cetyl Palmitat Alcohol, cetyl palmitate. Stearylalkohol 0,5 2 Stearyl 0. Cetylalkohol 3 2 Cetyl 3 2. Carbomer 0,3 0,3 0,3 Carbomer 0. Xanthan Gum 0,3 0,4 Xanthan Gum 0. C 1 2 Alkyl Benzoat 5 5 3 C 1 2 alkyl benzoate 5 5 3. Dicaprylyl Ether 2 3 Dicaprylyl Ether 2 3. Diethylhexylnaphthalat 3 diethylhexyl 3. Cyclomethicon 2 10 2 Cyclomethicone 2 10 2. Isohexadecan 2 3 Isohexadecane 2 3.

Propandiol 3 5 Emulsion NOPQRS Propanediol 3 5 emulsion NOPQRS. Titandioxid 2 4 Titanium dioxide 2 4. Zinkoxid 2 zinc oxide 2. Drometrizole Trisiloxane 3 Drometrizole trisiloxane 3. Ethylhexylmethoxycinnamat 6 5 Ethylhexylmethoxycinnamate 6 I behandelten Psoriasis Wasserstoffperoxid. Phenylbenzimidazol 0,5 2 1 Phenylbenzimidazole 0.

Homosalat 5 7 Homosalate 5 7. Butyl 3 butyl 3. Bis-Ethylhexyloxyphenol 2 3 Up-Ethylhexyloxyphenol 2 3. Octylsalicylat 5 octyl salicylate 5.

Octocrylen 3 octocrylene 3. Farbstoff nach Beispiel 1 0,25 0,5 0,75 1 ,0 1 ,25 1 ,5 A dye according to Example 1 0. PVP Hexadecen Copolymer 0,5 1 0,8 PVP hexadecene copolymer 0. Coenzym Q 10 0,2 0,02 0,3 Coenzyme Q 10 0. Vitamin E Acetat 0,2 0,3 0,8 0,5 Vitamin E acetate 0. Ethanol 50 5 2 40 15 Ethanol 50 5 2 40 Cocoatnidopropylbetain 0,3 Cocoatnidopropylbetain 0. Butyl Methoxydibenzoylmethan 0,5 3 Butyl methoxydibenzoylmethane 0.

Dinatrium Phenyl 2 1 Disodium phenyl 2 1. Dibenzimidazol Tetrasulfonat Dibenzimidazole tetrasulfonate. Farbstoff I behandelten Psoriasis Wasserstoffperoxid Beispiel 1 0,1 0,25 0,5 1 2 3 A dye according to Example 1 0. Farbstoff nach Beispiel 2 3 2 1 0,5 0,25 0,1 A dye according to Example 2 3 2 1 0.

Farbstoff nach Beispiel 3 0,1 0,25 0,5 1 2 3 A dye according to Example 3 0. Farbstoff nach Beispiel 4 3 2 1 0,5 0,25 0,1 A dye according to Example 4 3 2 1 0. Farbstoff nach Beispiel 5 0,5 0,5 0,5 0,5 0,5 0,5 A dye according to I behandelten Psoriasis Wasserstoffperoxid 5 0.

C 12 Alkyl Benzoat 3 C 12 alkyl benzoate 3. Butylenglycol 2 butylene glycol 2. C 2- 13 I behandelten Psoriasis Wasserstoffperoxid Tartrat 5 C 2- 13 alkyl tartrate 5. Cyclomethicon 4 2 Cyclomethicone 4 2. Dimethicon 3 dimethicone 3. PVP Hexadecen Copolymer 0,5 1 0. Ethylhexyloxyglycerin 0,5 Ethylhexyloxyglycerin 0.

Glycerin 5 7 3 8 S Glycerin 5 7 3 8 S. Butylenglycol 5 5 Butylene glycol 5 5. Metylpropandiol 4 Metylpropandiol 4. Vitamin E Acetat 0,3 0,2 0,5 Vitamin E acetate 0. Panthenol 0;5 I behandelten Psoriasis Wasserstoffperoxid 0,3 Panthenol 0; 5 0. Kreatinin 0,01 0,02 Creatinine 0. Creatin 0,1 0,2 Creatine 0. Trinatrium EDTA 0,3 0,2 0,2 0,2 0,2 0,5 Trisodium EDTA 0. Konservierungsmittel qsqsqsqsqsqs Preservatives qsqsqsqsqsqs. Wasser ad ad ad ad ad ad Water ad ad ad ad ad.

Emulsion ABC emulsion ABC. Cetylalkohol 2,5 2 Cetyl alcohol 2. Stearylalkohol 3 stearyl 3. PEG Stearat 3,5 PEG stearate 3. PEG Stearat 2 PEG stearate 2. Sorbitanstearat 0,8 sorbitan 0. C- Alkyl Benzoat 5 C alkyl benzoate 5. C 13 Alkyl Tartrat 7 C 13 alkyl tartrate 7.

Cyclomethicon 2 3 Cyclomethicone 2 3. Butylenglycol 1 butylene glycol 1. Isohexadecan 2 isohexadecane 2. Propylenglykol 5 Propylene glycol 5. Glycerin 5 7 Glycerin 5 7. Farbstoff nach Beispiel 1 1,0 A dye according to Example 1 1. Farbstoff nach Beispiel 2 I behandelten Psoriasis Wasserstoffperoxid A dye according to Example 2 2. Farbstoff nach Beispiel 3 1,5 A dye according to Example 3 1. Farbstoff nach Beispiel 4 I behandelten Psoriasis Wasserstoffperoxid ,5 A dye according to Example 4 1, 5.

Farbstoff nach Beispiel 5 1 ,0 A dye according to Example 5 1, 0. Octocrylen 2 octocrylene 2. Bis-Ethylhexyloxyphenol 3 Up-Ethylhexyloxyphenol 3. C8-C16 Alkylpolyglycoside 1 C8-C16 alkylpolyglycosides 1.

Vitamin E Acetat 0,6 0,5 0,2 Vitamin Psoriasis den Körper und die Hände acetate 0. BHT 0,1 BHT 0. Natriumhydroxid qsqs sodium qsqs. Kaliumhydroxid qs qs potassium hydroxide. Wasser ad ,0 ad ,0 ad ,0 Water Emulsion DEFG emulsion DEFG. Cetylalkohol 2 2 Cetyl 2 2. Cetylstearylalkohol 2 2 Cetylstearylalkohol 2 2.

PEG Stearat 4 PEG stearate 4. PEG Stearat 3 3 PEG Stearate 3 3. Tridecyl Trimellitate 5 Tridecyl trimellitate 5. C 12 Alkyl Benzoat 3 3 Learn more here 12 alkyl benzoate 3 3. Butylenglycol 8 Emulsion DEFG Butylene 8 emulsion DEFG. Cocoglyceride 2 cocoglycerides 2. Dicaprylyl Ether 2 2 Dicaprylyl Ether 2 2. Dimethicon 1 2 2 Dimethicone 1 2 2. Isohexadecan 3 isohexadecane 3. Glycerin 5 6 6 Glycerin I behandelten Psoriasis Wasserstoffperoxid 6 6.

Farbstoff nach Beispiel I behandelten Psoriasis Wasserstoffperoxid 0,5 0,5 0,5 0,5 A dye according to Example 1 0. Ethylhexylmethoxycinnama 5 4 4 t Ethylhexylmethoxycinnama 5 4 4 t.

Ethylhexyltriazon 2 1 Ethylhexyltriazon 2 1. Diethylhexylbutamidotriazo 1 Diethylhexylbutamidotriazo 1. Butyl 2,5 2 2 Butyl 2. Bis-Ethylhexyloxyphenol 2 Up-Ethylhexyloxyphenol 2. Vitamin E Acetat 0,2 0,3 0,3 Vitamin E acetate 0. Triethanolamin qsqs triethanolamine qsqs.

Wasser ad ,0 ad 00,0 ad ,0 ad Water ad The invention relates to protein-adhesive colouring agents, to the production thereof and to preparations containing just click for source colouring agents and to a method for colouring keratin-containing fibres, in particular for colouring human hair Try the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.

Substituted quinones or analogues as colouring agents WO A1. The invention relates to protein-adhesive colouring agents, to the production thereof and to preparations containing said colouring agents and to a method for colouring keratin-containing I behandelten Psoriasis Wasserstoffperoxid, in particular for colouring human hair. Verbindungen der Formel I Compounds of formula I.

Verbindungen nach Anspruch 1dadurch gekennzeichnet, dass der Substituent D ein Substituent der Formel II, III, IV, V, VI, VII, VIII, IX, X, I behandelten Psoriasis Wasserstoffperoxid oder XII ist, 2. Compounds according to claim 1, characterized in that the substituent D is a substituent of the formula II, III, IV, V, VI, VII, VIII, IX, X, XI or XII.

Verbindungen nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass Rt A bedeutet. Compounds according to claim 1 or 2, characterized in that A represents Rt. Compounds according to one or more of claims 1 to 3, characterized in that R 2 and R 3 mean H. Compounds I behandelten Psoriasis Wasserstoffperoxid to one or more of claims 1 to 4, characterized in that Sp is -C O. A process for the preparation of compounds of the formula I according to one or more of claims 1 to 5, characterized in that a compound of formula XIII.

Bedeutung haben, have meaning. M Alkalimetall- oder Erdalkalimetallkation, Halogen, OH oder H I behandelten Psoriasis Wasserstoffperoxid oder eine Verbindung der Formel XIII, worin R 2R3, R 4 und E eine in M alkali metal or alkaline earth metal cation, halogen, OH or H or a compound of formula XIII wherein R 2, R 3, R 4 and E in a. Anspruch 12, 3, 4 oder 5 angegebene Bedeutung haben, Claim 1, 2, 3, 4 or 5 have the meaning given.

Preparation comprising at least one compound of formula I according to one or more of claims 1 to 6th. Preparation according to claim 7, characterized in that it contains I behandelten Psoriasis Wasserstoffperoxid cosmetic, dermatological or pharmacologically acceptable carrier. A process for preparing a composition according to claim 8, characterized in that at least one compound of formula I according to one or more of claims 1 to 5 with a carrier and optionally with I behandelten Psoriasis Wasserstoffperoxid active or auxiliary substances are mixed.

The use of compounds of formula I, according to one or more of claims 1 to 5 as a protein adhesive dyes. Country of ref document: Kind code of ref document: EPA1EPB1US I behandelten Psoriasis Wasserstoffperoxid, US BiBTeXEndNoteRefMan. Patent Citations 10Non-Patent Citations 6Referenced by 1Classifications 26Legal Events 4. Filtering cosmetic composition containing a liposoluble filter polymer with hydrocarbonated structure and a filter silicone.

Cosmetic composition containing a dibenzoylmethane derivative and a particular neutral n-acylamino acid ester derivative; process for photostabilizing the dibenzoylmethane derivative.

Novel direct dyes containing an ascorbic acid-based unit, dye composition comprising them and process for dyeing human keratin materials using these dyes. Topical compositions containing osmolytes, useful e. EP Kind code of ref document:


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